Dissolved oxygen technologies as a novel strategy for non-healing wounds: a critical reviewDissolved oxygen technologies as a novel strategy for non-healing wounds: a critical review Ανασκόπηση Review 2022-09-282021enThis research work was supported by the Hellenic Foundation for Research and Innovation (HFRI) under the HFRI PhD Fellowship grant #940.Non-healing wounds are steadily becoming a global-health issue. Prolonged hypoxia propagates wound chronicity; yet, oxygenating treatments are considered inadequate to date. Dissolved oxygen (DO) in aqueous solutions introduces a novel approach to enhanced wound oxygenation, and is robustly evaluated for clinical applications. A systematic literature search was conducted, whereby experimental and clinical studies of DO technologies were categorized per engineering approach. Technical principles, methodology, endpoints and outcomes were analysed for both oxygenating and healing effects. Forty articles meeting our inclusion criteria were grouped as follows: DO solutions (17), oxygen (O2) dressings (9), O2 hydrogels (11) and O2 emulsions (3). All technologies improved wound oxygenation, each to a variable degree. They also achieved at least one statistically significant outcome related to wound healing, mainly in epithelialization, angiogenesis and collagen synthesis. Scarcity in clinical data and methodological variability precluded quantitative comparisons among the biotechnologies studied. DO technologies warrantee further evaluation for wound oxygenation in the clinical setting. Standardised methodologies and targeted research questions are pivotal to facilitate global integration in healthcare.http://creativecommons.org/licenses/by/4.0/Wound Repair and Regeneration: The International Journal of Tissue Repair and Regeneration2961062–1079 Venieri Danai Βενιερη Δαναη Ntentakis Dimitrios Ντεντακης Δημητριος Ntentaki Anastasia Maria Kalomoiris Loukas Kalogerakis Nikos Καλογερακης Νικος Delavogia Eleni Arkadopoulos Nikolaos Wiley Dissolved oxygen Dissolved oxygen technologies Healing Oxygen solutions Wound oxygen