Gene expression data analysis for classification of bipolar disordersGene expression data analysis for classification of bipolar disorders Πλήρης Δημοσίευση σε Συνέδριο Conference Full Paper 2018-10-262016enIn recent years DNA microarray technology has become a widely used tool for gene expression profile analysis. This technology can be useful for the early diagnosis of complex diseases such as bipolar disorder, providing useful information for its genetic background. The ability to classify bipolar disorders may have a major impact on our understanding of disease pathophysiology, as well as it may be essential for guiding the appropriate treatment strategy and determining prognosis for successful targeted therapy. In this preliminary meta-data-study, we propose an analytic framework for biomarker identification aiming at prediction of bipolar disorder, by considering peripheral gene expression differences between bipolar patients and healthy controls. The aim of this paper is to extract a significant genomic signature for which biological knowledge may already exists and discover novel genomic information that can motivate further analysis. We study two classification algorithms based on support and relevance vector machines. The observed results indicate that the latter approach performs better in the specific biological environment.http://creativecommons.org/licenses/by/4.0/494-50014th Mediterranean Conference on Medical and Biological Engineering and ComputingIFMBE Proceedings Leska Valsamo Λεσκα Βαλσαμω Bei Aikaterini Μπεη Αικατερινη Petrakis Evripidis Πετρακης Ευριπιδης Zervakis Michail Ζερβακης Μιχαηλ Springer Verlag Bipolar disorder Microarray analysis Recursive feature elimination Significance analysis of Microarrays Support & relevance vector machines