Regional scale hydrologic modeling of a karst-dominant geomorphology: the case study of the Island of CreteRegional scale hydrologic modeling of a karst-dominant geomorphology: the case study of the Island of Crete Peer-Reviewed Journal Publication Δημοσίευση σε Περιοδικό με Κριτές 2018-10-032016enCrete Island (Greece) is a karst dominated region that faces limited water supply and increased seasonal demand, especially during summer for agricultural and touristic uses. In addition, due to the mountainous terrain, interbasin water transfer is very limited. The resulting water imbalance requires a correct quantification of available water resources in view of developing appropriate management plans to face the problem of water shortage. The aim of this work is the development of a methodology using the SWAT model and a karst-flow model (KSWAT, Karst SWAT model) for the quantification of a spatially and temporally explicit hydrologic water balance of karst-dominated geomorphology in order to assess the sustainability of the actual water use. The application was conducted in the Island of Crete using both hard (long time series of streamflow and spring monitoring stations) and soft data (i.e. literature information of individual processes). The KSWAT model estimated the water balance under normal hydrological condition as follows: 6400 Mm3/y of precipitation, of which 40% (2500 Mm3/y) was lost through evapotranspiration, 5% was surface runoff and 55% percolated into the soil contributing to lateral flow (2%), and recharging the shallow (9%) and deep aquifer (44%). The water yield was estimated as 22% of precipitation, of which about half was the contribution from spring discharges (9% of precipitation). The application of the KSWAT model increased our knowledge about water resources availability and distribution in Crete under different hydrologic conditions. The model was able to capture the hydrology of the karst areas allowing a better management and planning of water resources under scarcity.http://creativecommons.org/licenses/by/4.0/Journal of Hydrology54064-81 Malagò Anna Efstathiou Dionysios Ευσταθιου Διονυσιος Bouraoui Fayçal Nikolaidis Nikolaos Νικολαιδης Νικολαος Franchini Marco Bidoglio, Giovanni Kritsotakis Marinos Elsevier Crete Karst Mediterranean Multi-site calibration SWAT Water balance