Mining cross-frequency coupling microstates from resting state MEG: an application to mild traumatic brain injuryMining cross-frequency coupling microstates from resting state MEG: an application to mild traumatic brain injury Πλήρης Δημοσίευση σε Συνέδριο Conference Full Paper 2018-10-092016enRecent studies have investigated the possible role of dynamic functional connectivity and the role of cross-frequency coupling (CFC) to provide the substrate for reliable biomarkers of brain disorders. In this study, we analyzed time-varying CFC profiles from resting state Magnetoencephal-ographic recordings of 30 mild Traumatic Brain Injury (mTBI) patients and 50 normal controls. Interactions among sensors at specific pairs of frequency bands were computed via estimation of phase-to-amplitude couplings. We then computed time-varying functional connectivity graphs that were described in terms of segregation (local efficiency, LE) and integration (global efficiency, GE) and mapped those graphs to time series of GE/LE estimates. The resulting dynamic network revealed transitions between a limited number of microstates for mTBI subjects compared to controls. The significant differences in transition probability between the two groups, along with the limited repertoire of possible states, can form the basis for a robust dynamic connectomic biomarker for the diagnosis of mTBI.http://creativecommons.org/licenses/by/4.0/5513-551638th Annual International Conference of the IEEE Engineering in Medicine and Biology SocietyProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS Antonakakis Marios Αντωνακακης Μαριος Dimitriadis Stavros I. Zervakis Michail Ζερβακης Μιχαηλ Papanicolaou, Andrew C Zouridakis, George Institute of Electrical and Electronics Engineers Measurement Time series analysis Couplings Frequency control Sensors Prototypes Brain