Altered rich-club and frequency-dependent subnetwork organization in mild traumatic brain injury: a MEG resting-state studyAltered rich-club and frequency-dependent subnetwork organization in mild traumatic brain injury: a MEG resting-state study Peer-Reviewed Journal Publication Δημοσίευση σε Περιοδικό με Κριτές 2018-04-182017enFunctional brain connectivity networks exhibit “small-world” characteristics and some of these networks follow a “rich-club” organization, whereby a few nodes of high connectivity (hubs) tend to connect more densely among themselves than to nodes of lower connectivity. The Current study followed an “attack strategy” to compare the rich-club and small-world network organization models using Magnetoencephalographic (MEG) recordings from mild traumatic brain injury (mTBI) patients and neurologically healthy controls to identify the topology that describes the underlying intrinsic brain network organization. We hypothesized that the reduction in global efficiency caused by an attack targeting a model’s hubs would reveal the “true” underlying topological organization. Connectivity networks were estimated using mutual information as the basis for cross-frequency coupling. Our results revealed a prominent rich-club network organization for both groups. In particular, mTBI patients demonstrated hyper-synchronization among rich-club hubs compared to controls in the δ band and the δ-γ1, θ-γ1, and β-γ2 frequency pairs. Moreover, rich-club hubs in mTBI patients were overrepresented in right frontal brain areas, from θ to γ1 frequencies, and underrepresented in left occipital regions in the δ-β, δ-γ1, θ-β, and β-γ2 frequency pairs. These findings indicate that the rich-club organization of resting-state MEG, considering its role in information integration and its vulnerability to various disorders like mTBI, may have a significant predictive value in the development of reliable biomarkers to help the validation of the recovery from mTBI. Furthermore, the proposed approach might be used as a validation tool to assess patient recovery. http://creativecommons.org/licenses/by/4.0/Frontiers in Human Neuroscience11Antonakakis_et_al_Front. Hum. Neurosci._11_2017.pdfChania [Greece]Library of TUC2018-04-18application/pdf6.7 MBfree Antonakakis Marios Αντωνακακης Μαριος Dimitriadis Stavros I. Zervakis Michail Ζερβακης Μιχαηλ Papanicolaou, Andrew C Zouridakis, George Frontiers Media Cross-frequency coupling Intrinsic networks Magnetoencephalography (MEG) Mild traumatic brain injury Network resilience