Integrating microarray data and gene regulatory networks: survey and critical considerationsIntegrating microarray data and gene regulatory networks: survey and critical considerations Πλήρης Δημοσίευση σε Συνέδριο Conference Full Paper 2015-10-252011enMicroarray gene expression and gene regulatory interactions are two of the most significant data sources in the areas of molecular biology and biotechnology. In this article we survey existing methods and tools supporting the integration of these two data sources. We start with gene regulatory network reconstruction methods focusing on the reconstruction using microarray experiments. Then we discuss methods and tools for gene expression data analysis based on gene regulatory network knowledge and we review algorithms and tools for gene regulatory networks selection using microarray data. Finally we introduce a new methodology for the identification of differentially expressed functional paths or sub-paths within a gene regulatory network using microarray data analysis.http://creativecommons.org/licenses/by/4.0/1-410th International Workshop on Biomedical Engineering Zervakis Michail Ζερβακης Μιχαηλ Potamias, Georgios Moustakis Vasilis Μουστακης Βασιλης Koumakis, Leonidas Institute of Electrical and Electronics Engineers Basic medical sciences Basic sciences, Medical Biomedical sciences Health sciences Preclinical sciences Sciences, Medical medical sciences basic medical sciences basic sciences medical biomedical sciences health sciences preclinical sciences sciences medical Gene expression Bioinformatics Data analysis Biological system modeling Data mining Cancer