Comparative proteomic analysis of hypertrophic chondrocytes in osteoarthritisComparative proteomic analysis of hypertrophic chondrocytes in osteoarthritis Peer-Reviewed Journal Publication Δημοσίευση σε Περιοδικό με Κριτές 2015-10-252015enOsteoarthritis (OA) is a multi-factorial disease leading progressively to loss of articular cartilage and subsequently to loss of joint function. While hypertrophy of chondrocytes is a physiological process implicated in the longitudinal growth of long bones, hypertrophy-like alterations in chondrocytes play a major role in OA. We performed a quantitative proteomic analysis in osteoarthritic and normal chondrocytes followed by functional analyses to investigate proteome changes and molecular pathways involved in OA pathogenesis.http://creativecommons.org/licenses/by/4.0/Clinical proteomics1121-16 Zervakis Michalis Ζερβακης Μιχαλης Ioanna Papathanasiou Vassiliki Gkretsi Kalliopi Kalantzaki Anastassios Economou Konstantinos Malizos Konstantinos C. Tsolis BioMed Central Basic medical sciences Basic sciences, Medical Biomedical sciences Health sciences Preclinical sciences Sciences, Medical medical sciences basic medical sciences basic sciences medical biomedical sciences health sciences preclinical sciences sciences medical