The role of the glycolysis-related genes in brain gliomas treatment designThe role of the glycolysis-related genes in brain gliomas treatment design Πλήρης Δημοσίευση σε Συνέδριο Conference Full Paper 2015-10-242011enThe aim of this study is to reveal the significance of glycolysis-related genes in the design of new brain gliomas treatment protocols. Towards this direction a feature selection and classification method, embedding the Relief-F filter criterion under a Support Vector Machines (SVM) classifier, has been introduced focusing on the identification of significant genetic alterations related to glycolysis. In particular a genomic (Microarray Expression) dataset, consisting of 14 glioma patients has been used for the statistical analysis. The results have demonstrated that a specific group of gene markers (HK, PGI, PFK, ALDO, GAPDH, PGK, PGM, ENO, PK, LDH, PDH and MDH) directly related to cell glycolysis, have a great impact on the discrimination of different grades of gliomas malignancy (AUROC of 0.98), thus leading to the conclusion that these markers could establish the foundations for new therapeutic approaches.http://creativecommons.org/licenses/by/4.0/377-3805th European Conference of the International Federation for Medical and Biological Engineering Zervakis Michalis Ζερβακης Μιχαλης M.G. Kounelakis G.C. Giakos X. Kotsiakis Springer Verlag Clinical laboratory technicians Medical laboratory technicians medical technologists clinical laboratory technicians medical laboratory technicians