Simulating radiotherapy effect in high-grade glioma by using diffusive modeling and brain atlasesSimulating radiotherapy effect in high-grade glioma by using diffusive modeling and brain atlases Peer-Reviewed Journal Publication Δημοσίευση σε Περιοδικό με Κριτές 2015-10-242012enApplying diffusive models for simulating the spatiotemporal change of concentration of tumour cells is a modern application of predictive oncology. Diffusive models are used for modelling glioblastoma, the most aggressive type of glioma. This paper presents the results of applying a linear quadratic model for simulating the effects of radiotherapy on an advanced diffusive glioma model. This diffusive model takes into consideration the heterogeneous velocity of glioma in gray and white matter and the anisotropic migration of tumor cells, which is facilitated along white fibers. This work uses normal brain atlases for extracting the proportions of white and gray matter and the diffusion tensors used for anisotropy. The paper also presents the results of applying this glioma model on real clinical datasetshttp://creativecommons.org/licenses/by/4.0/BioMed Research International20121-9Roniotis_et_al._Biomed Res. Int._2012.pdfChania [Greece]Library of TUC2020-12-29application/pdf2.9 MBfree Zervakis Michalis Ζερβακης Μιχαλης Roniotis Alexandros Ρονιωτης Αλεξανδρος Sakkalis, Vangelis Manikis Georgios Μανικης Γεωργιος Marias Kostas Hindawi Publishing Corporation Clinical laboratory technicians Medical laboratory technicians medical technologists clinical laboratory technicians medical laboratory technicians