Intertrial coherence and causal interaction among independent EEG componentsIntertrial coherence and causal interaction among independent EEG components Peer-Reviewed Journal Publication Δημοσίευση σε Περιοδικό με Κριτές 2015-10-232011enOver the past few years there has been an increased interest in studying the underlying neural mechanism of attention and cognitive brain activity. This paper aims towards identifying and analyzing distinct responses in an auditory working memory paradigm, as independent components with variable latency, frequency and phase characteristics. The event-related nature of components (either phase or non-phase-locked) over multiple trials is thoroughly examined through intertrial coherence measures. Furthermore, the functional coupling of independent components is investigated through the concept of partial directed coherence depicted as a directed graph. Using these tools, the paper compares issues of activation, connectivity and directionality in the synchronization maps of two populations, of control and Alzheimer's subjects. The results on real data from an oddball experiment verify and further enhance the findings of previous studies and illustrate the potential of the proposed analysis framework. http://creativecommons.org/licenses/by/4.0/Journal of Neuroscience Methods1972302–314 Zervakis Michail Ζερβακης Μιχαηλ Michalopoulos Konstantinos Μιχαλοπουλος Κωνσταντινος Iordanidou Vasiliki Ιορδανιδου Βασιλικη Sakkalis, Vangelis Elsevier ERP Evoked activity Induced oscillations Intertrial coherence ICA Synchronization Partial directed coherence Alzheimer's disease