In silico modeling and global optimization of dynamic bio-optical processes for probing, in vivo, biological features of neoplasiaIn silico modeling and global optimization of dynamic bio-optical processes for probing, in vivo, biological features of neoplasia Peer-Reviewed Journal Publication Δημοσίευση σε Περιοδικό με Κριτές 2015-10-192012enWe present the first in silico simulation of biomarker uptake kinetics and of the associated dynamic optical signals, measured in vivo in neoplastic epithelial tissue. We introduce a new, non-invasive method for estimating and mapping of both structural and functional, neoplasia-correlated parameters. The method relies on model-based fitting of dynamic optical signals, measured in vivo, and on solving the inverse problem with the aid of global sensitivity analysis and global optimization approaches.http://creativecommons.org/licenses/by/4.0/Biomedical Engineering and Biotechnology Balas Costas Μπαλας Κωστας Papoutsoglou Georgios Παπουτσογλου Γεωργιος Stamatiadou M. Institute of Electrical and Electronics Engineers