Modeling healthcare system-of-systems: a mathematical programming approachModeling healthcare system-of-systems: a mathematical programming approach Peer-Reviewed Journal Publication Δημοσίευση σε Περιοδικό με Κριτές 2015-10-052013enTraditional system analysis and design approaches seem insufficient to model healthcare systems, given their complexity, the presence of uncertainty, and scale. To overcome these difficulties, a system-of-systems approach is adopted. In this paper, we present a methodological framework for modeling healthcare systems and devising strategies that improve the health level of a population. The problem is formulated as a nonlinear programming model in which the objective is to optimize the population's health level, appropriately defined, by taking into account several constraints. The resulting policies could improve the sustainability of healthcare systems, and, consequently, the well-being of people and the overall sustainability of corresponding countries.http://creativecommons.org/licenses/by/4.0/IEEE Systems Journal74571-580 Yannis Phillis Φιλλης Ιωαννης Grigoroudis Evangelos Γρηγορουδης Ευαγγελος Institute of Electrical and Electronics Engineers Agencies, Health systems HSAs (Health planning) health systems agencies agencies health systems hsas health planning