Rapid determination of octanol-water partition coefficient using vortex-sssisted liquid-liquid microextractionRapid determination of octanol-water partition coefficient using vortex-sssisted liquid-liquid microextraction Peer-Reviewed Journal Publication Δημοσίευση σε Περιοδικό με Κριτές 2015-09-252014enAbstract Vortex-assisted liquid–liquid microextraction (VALLME) coupled with high- performance liquid chromatography (HPLC) is proposed here for the rapid determination of octanol–water partitioning coefficients (K ow). VALLME uses vortex agitation, a mild emulsification procedure, to disperse microvolumes of octanol in the aqueous phase thus increasing the interfacial contact area and ensuring faster partitioning rates. With VALLME, 2 min were enough to achieve equilibrium conditions between the octanolic and aqueous .http://creativecommons.org/licenses/by/4.0/Journal of Chromatography A13301-5 Elefteria Psillakis Antonio Canals Konstantina Tyrovola Anna Mastromichali Iván P Román Elsevier EXPERIMENTAL