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Ιδρυματικό Αποθετήριο [SANDBOX]
Πολυτεχνείο Κρήτης
Πολυτεχνείο Κρήτης
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| URI: | http://purl.tuc.gr/dl/dias/5FED8CF9-1DDD-47B9-984D-EED9CFE22043 | ||
| Έτος | 2023 | ||
| Τύπος | Δημοσίευση σε Περιοδικό με Κριτές | ||
| Άδεια Χρήσης |
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| Βιβλιογραφική Αναφορά | A. Papagiannopoulos, S.-P. Nikolakis, A. Pamvouxoglou, and E. Koutsopoulou, “Physicochemical properties of electrostatically crosslinked carrageenan/chitosan hydrogels and carrageenan/chitosan/Laponite nanocomposite hydrogels,” Int. J. Biol. Macromol., vol. 225, pp. 565-573, Jan. 2023, doi: 10.1016/j.ijbiomac.2022.11.113. https://doi.org/10.1016/j.ijbiomac.2022.11.113 | ||
| Εμφανίζεται στις Συλλογές |
In this work physical carrageenan/chitosan (Car/Chit) hydrogels are prepared by electrostatic complexation between the two oppositely charged polysaccharides. The hydrogels have storage moduli in the order of 5–10 kPa and swelling ratios in the order of 5000–6000 %. At conditions where both polysaccharides are highly charged (pH 5) the swelling ratios are lower than the ones at conditions of lower dissociation i.e., at pH 2 and 7 and the opposite trend is found for the storage modulus. Chit appears to act as a crosslinker for Car as increasing its concentration the swelling ratio decreases and the moduli increase. The hydrogels can incorporate the nanoclay Laponite (Lap) and form hybrid nanocomposites where the intercalation by the two biopolymers leads to exfoliation of the clay nanoplatelets in the presence of both Car and Chit. The composite hydrogels retain the mechanical properties of the Car/Chit hydrogels at the studied pH range (pH 2 to pH 7). This shows the prepared hydrogels can be potentially used as multifunctional biomaterials for drug delivery, tissue engineering and bone regeneration applications.
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