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Ιδρυματικό Αποθετήριο [SANDBOX]
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| URI | http://purl.tuc.gr/dl/dias/0E01F6FA-2EEE-4020-9392-8C17D0656724 | - |
| Αναγνωριστικό | https://doi.org/10.3390/ijms23137132 | - |
| Αναγνωριστικό | https://www.mdpi.com/1422-0067/23/13/7132 | - |
| Γλώσσα | en | - |
| Μέγεθος | 25 pages | en |
| Τίτλος | Outcome prediction in critically-ill patients with venous thromboembolism and/or cancer using machine learning algorithms: external validation and comparison with scoring systems | en |
| Δημιουργός | Danilatou Vasiliki | en |
| Δημιουργός | Nikolakakis Stylianos | en |
| Δημιουργός | Νικολακακις Στυλιανος | el |
| Δημιουργός | Antonakaki Despoina | en |
| Δημιουργός | Tzagkarakis Christos | en |
| Δημιουργός | Mavroidis Dimitrios | en |
| Δημιουργός | Kostoulas, Theodoros | en |
| Δημιουργός | Ioannidis Sotirios | en |
| Δημιουργός | Ιωαννιδης Σωτηριος | el |
| Εκδότης | MDPI | en |
| Περίληψη | Intensive care unit (ICU) patients with venous thromboembolism (VTE) and/or cancer suffer from high mortality rates. Mortality prediction in the ICU has been a major medical challenge for which several scoring systems exist but lack in specificity. This study focuses on two target groups, namely patients with thrombosis or cancer. The main goal is to develop and validate interpretable machine learning (ML) models to predict early and late mortality, while exploiting all available data stored in the medical record. To this end, retrospective data from two freely accessible databases, MIMIC-III and eICU, were used. Well-established ML algorithms were implemented utilizing automated and purposely built ML frameworks for addressing class imbalance. Prediction of early mortality showed excellent performance in both disease categories, in terms of the area under the receiver operating characteristic curve (𝐴𝑈𝐶–𝑅𝑂𝐶): VTE-MIMIC-III 0.93, eICU 0.87, cancer-MIMIC-III 0.94. On the other hand, late mortality prediction showed lower performance, i.e., 𝐴𝑈𝐶–𝑅𝑂𝐶: VTE 0.82, cancer 0.74–0.88. The predictive model of early mortality developed from 1651 VTE patients (MIMIC-III) ended up with a signature of 35 features and was externally validated in 2659 patients from the eICU dataset. Our model outperformed traditional scoring systems in predicting early as well as late mortality. Novel biomarkers, such as red cell distribution width, were identified. | en |
| Τύπος | Peer-Reviewed Journal Publication | en |
| Τύπος | Δημοσίευση σε Περιοδικό με Κριτές | el |
| Άδεια Χρήσης | http://creativecommons.org/licenses/by/4.0/ | en |
| Ημερομηνία | 2023-09-13 | - |
| Ημερομηνία Δημοσίευσης | 2022 | - |
| Θεματική Κατηγορία | Venous thromboembolism | en |
| Θεματική Κατηγορία | Cancer | en |
| Θεματική Κατηγορία | Mortality | en |
| Θεματική Κατηγορία | ICU | en |
| Θεματική Κατηγορία | Interpretable machine learning | en |
| Βιβλιογραφική Αναφορά | V. Danilatou, S. Nikolakakis, D. Antonakaki, C. Tzagkarakis, D. Mavroidis, T. Kostoulas, and S. Ioannidis, “Outcome prediction in critically-ill patients with venous thromboembolism and/or cancer using machine learning algorithms: external validation and comparison with scoring systems,” Int. J. Mol. Sci., vol. 23, no. 13, June 2022, doi: 10.3390/ijms23137132. | en |
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