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Dissolved oxygen technologies as a novel strategy for non-healing wounds: a critical review

Venieri Danai, Ntentakis Dimitrios, Ntentaki Anastasia Maria, Kalomoiris Loukas, Kalogerakis Nikos, Delavogia Eleni, Arkadopoulos Nikolaos

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URIhttp://purl.tuc.gr/dl/dias/D9F1618B-F9F1-4401-AF86-30508A12BEF0-
Identifierhttps://doi.org/10.1111/wrr.12972-
Identifierhttps://onlinelibrary.wiley.com/doi/10.1111/wrr.12972-
Languageen-
Extent18 pagesen
TitleDissolved oxygen technologies as a novel strategy for non-healing wounds: a critical reviewen
CreatorVenieri Danaien
CreatorΒενιερη Δαναηel
CreatorNtentakis Dimitriosen
CreatorΝτεντακης Δημητριοςel
CreatorNtentaki Anastasia Mariaen
CreatorKalomoiris Loukasen
CreatorKalogerakis Nikosen
CreatorΚαλογερακης Νικοςel
CreatorDelavogia Elenien
CreatorArkadopoulos Nikolaosen
PublisherWileyen
Content SummaryNon-healing wounds are steadily becoming a global-health issue. Prolonged hypoxia propagates wound chronicity; yet, oxygenating treatments are considered inadequate to date. Dissolved oxygen (DO) in aqueous solutions introduces a novel approach to enhanced wound oxygenation, and is robustly evaluated for clinical applications. A systematic literature search was conducted, whereby experimental and clinical studies of DO technologies were categorized per engineering approach. Technical principles, methodology, endpoints and outcomes were analysed for both oxygenating and healing effects. Forty articles meeting our inclusion criteria were grouped as follows: DO solutions (17), oxygen (O2) dressings (9), O2 hydrogels (11) and O2 emulsions (3). All technologies improved wound oxygenation, each to a variable degree. They also achieved at least one statistically significant outcome related to wound healing, mainly in epithelialization, angiogenesis and collagen synthesis. Scarcity in clinical data and methodological variability precluded quantitative comparisons among the biotechnologies studied. DO technologies warrantee further evaluation for wound oxygenation in the clinical setting. Standardised methodologies and targeted research questions are pivotal to facilitate global integration in healthcare.en
Type of ItemΑνασκόπησηel
Type of ItemReviewen
Licensehttp://creativecommons.org/licenses/by/4.0/en
Date of Item2022-09-28-
Date of Publication2021-
SubjectDissolved oxygenen
SubjectDissolved oxygen technologiesen
SubjectHealingen
SubjectOxygen solutionsen
SubjectWound oxygenen
Bibliographic CitationD. P. Ntentakis, A. M. Ntentaki, E. Delavogia, L. Kalomoiris, D. Venieri, N. Arkadopoulos, and N. Kalogerakis, “Dissolved oxygen technologies as a novel strategy for non‐healing wounds: a critical review,” Wound Rep. Reg., vol. 29, no. 6, pp. 1062–1079, Nov.-Dec. 2021, doi: 10.1111/wrr.12972.en

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