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Improving the sensitivity of task-related Functional Magnetic Resonance Imaging data using generalized canonical correlation analysis

Kosteletou Emmanouela, Simos Panagiotis G., Kavroulakis Eleftherios, Antypa Despina, Maris Thomas G., Liavas Athanasios, Karakasis Paris, Papadaki Efrosini

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URIhttp://purl.tuc.gr/dl/dias/0F72CCE3-7DD9-4A39-A7D5-7FC81DAF8554-
Identifierhttps://doi.org/10.3389/fnhum.2021.771668-
Identifierhttps://www.frontiersin.org/articles/10.3389/fnhum.2021.771668/full-
Languageen-
Extent11 pagesen
TitleImproving the sensitivity of task-related Functional Magnetic Resonance Imaging data using generalized canonical correlation analysisen
CreatorKosteletou Emmanouelaen
CreatorSimos Panagiotis G.en
CreatorKavroulakis Eleftheriosen
CreatorAntypa Despinaen
CreatorMaris Thomas G.en
CreatorLiavas Athanasiosen
CreatorΛιαβας Αθανασιοςel
CreatorKarakasis Parisen
CreatorΚαρακασης Παριςel
CreatorPapadaki Efrosinien
PublisherFrontiers Mediaen
Content SummaryGeneral Linear Modeling (GLM) is the most commonly used method for signal detection in Functional Magnetic Resonance Imaging (fMRI) experiments, despite its main limitation of not taking into consideration common spatial dependencies between voxels. Multivariate analysis methods, such as Generalized Canonical Correlation Analysis (gCCA), have been increasingly employed in fMRI data analysis, due to their ability to overcome this limitation. This study, evaluates the improvement of sensitivity of the GLM, by applying gCCA to fMRI data after standard preprocessing steps. Data from a block-design fMRI experiment was used, where 25 healthy volunteers completed two action observation tasks at 1.5T. Whole brain analysis results indicated that the application of gCCA resulted in significantly higher intensity of activation in several regions in both tasks and helped reveal activation in the primary somatosensory and ventral premotor area, theoretically known to become engaged during action observation. In subject-level ROI analyses, gCCA improved the signal to noise ratio in the averaged timeseries in each preselected ROI, and resulted in increased extent of activation, although peak intensity was considerably higher in just two of them. In conclusion, gCCA is a promising method for improving the sensitivity of conventional statistical modeling in task related fMRI experiments.en
Type of ItemPeer-Reviewed Journal Publicationen
Type of ItemΔημοσίευση σε Περιοδικό με Κριτέςel
Licensehttp://creativecommons.org/licenses/by/4.0/en
Date of Item2022-08-04-
Date of Publication2021-
SubjectTask-related fMRIen
SubjectSignal sensitivityen
SubjectfMRIen
SubjectgCCA methoden
SubjectAction observationen
SubjectSignal intensityen
Bibliographic CitationE. Kosteletou, P.G. Simos, E. Kavroulakis, D. Antypa, T. G. Maris, A. P. Liavas, P. A. Karakasis and E. Papadaki, “Improving the sensitivity of task-related Functional Magnetic Resonance Imaging data using generalized canonical correlation analysis,” Front. Hum. Neurosci., vol. 15, Dec. 2021, doi: 10.3389/fnhum.2021.771668.en

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