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Institutional Repository [SANDBOX]
Technical University of Crete
Technical University of Crete
EN
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| URI: | http://purl.tuc.gr/dl/dias/2CD4C8C1-7DEE-4F73-BBE1-E1E186A01B16 | ||
| Year | 2017 | ||
| Type of Item | Conference Full Paper | ||
| License |
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| Bibliographic Citation | D. A. C. Ntellis, E. S. Bei, D. Kafetzopoulos and M. Zervakis, "Assembly of gene expression networks based on a breast cancer signature," in 5th International Work-Conference on Bioinformatics and Biomedical Engineering, 2017, pp. 62-73. doi: 10.1007/978-3-319-56154-7_7 https://doi.org/10.1007/978-3-319-56154-7_7 | ||
| Appears in Collections |
The aim of this paper is to provide a snapshot of functional networks with central nodes (hubs) relying on the behavior of genes linked to a specific interaction network. Utilizing a ‘breast cancer signature’, a Bayesian approach is applied for the construction of gene interaction networks from different populations. We demonstrate that the hub genes of the differentiating network between cancer and control states can be regarded as potential markers for breast cancer. Furthermore, the differentiating subnetworks can be informative of the phenotype and provide new knowledge about the functional interactions and molecular pathways involved in breast cancer.
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