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Modeling and simulation of the formation of vascular network

Manoussaki, D.

Πλήρης Εγγραφή

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Περίληψη

The formation of blood vessels is driven by chemical and mechanical interactions betweenthe cells and their extracellular matrix. New vasculature can emerge in the presence of angiogenicfactors or as a result of cell traction forces onto the extracellular matrix. The respective contributionof chemical or mechanical events during angiogenesis is still unclear.We present a mathematical model that incorporates such interactions and examine the conditionsnecessary for the formation of pattern. The model treats the extracellular matrix as a linear viscoelasticmaterial and cellular movement either as a process influenced by the local strain field or as a chemotacticmovement, in response to chemical gradients.

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