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Indentification of altered MET network in oral cancer progression based on nonparametric network design

Zervakis Michalis, Dimitrios Fotiadis, K. Kalantzaki, E.S. Bei, K.P. Exarchos

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URIhttp://purl.tuc.gr/dl/dias/9A58FEFE-A3CB-4C75-BB85-CCC76164396F-
Identifierhttps://doi.org/10.1109/EMBC.2013.6609565-
Languageen-
Extent4 pagesen
TitleIndentification of altered MET network in oral cancer progression based on nonparametric network designen
CreatorZervakis Michalisen
CreatorΖερβακης Μιχαληςel
Creator Dimitrios Fotiadisen
CreatorK. Kalantzakien
CreatorE.S. Beien
CreatorK.P. Exarchosen
PublisherInstitute of Electrical and Electronics Engineersen
Content SummaryOral cancer is characterized by multiple genetic events such as alterations of a number of oncogenes and tumour suppressor genes. The aim of this study is to identify genes and their functional interactions that may play a crucial role on a specific disease-state, especially during oral cancer progression. We examine gene interaction networks on blood genomic data, obtained from twenty three oral cancer patients at four different time stages. We generate the gene-gene networks from sparse experimental temporal data using two methods, Partial Correlations and Kernel Density Estimation, in order to capture genetic interactions. The network study reveals an altered MET (hepatocyte growth factor receptor) network during oral cancer progression, which is further analyzed in relation to other studies. en
Type of ItemΠλήρης Δημοσίευση σε Συνέδριοel
Type of ItemConference Full Paperen
Licensehttp://creativecommons.org/licenses/by/4.0/en
Date of Item2015-10-25-
Date of Publication2013-
SubjectBiomedical scientistsen
SubjectHealth scientistsen
Subjectmedical scientistsen
Subjectbiomedical scientistsen
Subjecthealth scientistsen
Bibliographic CitationK. Kalantzaki, E.S. Bei, K.P. Exarchos, M. Zervakis, D. Fotiadis, M. Garofalakis ,"Indentification of altered MET network in oral cancer progression based on nonparametric network design," in 2013 35th Annual Inter. Conf. of the IEEE Eng. in Medicine and Biol. Society (EMBC) ,pp. 575-578 .doi:10.1109/EMBC.2013.6609565en

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