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Indentification of altered MET network in oral cancer progression based on nonparametric network design

Zervakis Michalis, Dimitrios Fotiadis, K. Kalantzaki, E.S. Bei, K.P. Exarchos

Απλή Εγγραφή


URIhttp://purl.tuc.gr/dl/dias/9A58FEFE-A3CB-4C75-BB85-CCC76164396F-
Αναγνωριστικόhttps://doi.org/10.1109/EMBC.2013.6609565-
Γλώσσαen-
Μέγεθος4 pagesen
ΤίτλοςIndentification of altered MET network in oral cancer progression based on nonparametric network designen
ΔημιουργόςZervakis Michalisen
ΔημιουργόςΖερβακης Μιχαληςel
Δημιουργός Dimitrios Fotiadisen
ΔημιουργόςK. Kalantzakien
ΔημιουργόςE.S. Beien
ΔημιουργόςK.P. Exarchosen
ΕκδότηςInstitute of Electrical and Electronics Engineersen
ΠερίληψηOral cancer is characterized by multiple genetic events such as alterations of a number of oncogenes and tumour suppressor genes. The aim of this study is to identify genes and their functional interactions that may play a crucial role on a specific disease-state, especially during oral cancer progression. We examine gene interaction networks on blood genomic data, obtained from twenty three oral cancer patients at four different time stages. We generate the gene-gene networks from sparse experimental temporal data using two methods, Partial Correlations and Kernel Density Estimation, in order to capture genetic interactions. The network study reveals an altered MET (hepatocyte growth factor receptor) network during oral cancer progression, which is further analyzed in relation to other studies. en
ΤύποςΠλήρης Δημοσίευση σε Συνέδριοel
ΤύποςConference Full Paperen
Άδεια Χρήσηςhttp://creativecommons.org/licenses/by/4.0/en
Ημερομηνία2015-10-25-
Ημερομηνία Δημοσίευσης2013-
Θεματική ΚατηγορίαBiomedical scientistsen
Θεματική ΚατηγορίαHealth scientistsen
Θεματική Κατηγορίαmedical scientistsen
Θεματική Κατηγορίαbiomedical scientistsen
Θεματική Κατηγορίαhealth scientistsen
Βιβλιογραφική ΑναφοράK. Kalantzaki, E.S. Bei, K.P. Exarchos, M. Zervakis, D. Fotiadis, M. Garofalakis ,"Indentification of altered MET network in oral cancer progression based on nonparametric network design," in 2013 35th Annual Inter. Conf. of the IEEE Eng. in Medicine and Biol. Society (EMBC) ,pp. 575-578 .doi:10.1109/EMBC.2013.6609565en

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