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MiRNA based pathway analysis tool in nephroblastoma as a proof of principle for other cancer domains

Zervakis Michalis, Moustakis Vasilis, Potamias, Georgios, L. Koumakis, N. Graf

Απλή Εγγραφή


URIhttp://purl.tuc.gr/dl/dias/AFA56D75-D910-4B69-BCAB-B0AD65287C01-
Αναγνωριστικόhttps://doi.org/10.1109/BIBE.2014.15-
Γλώσσαen-
Μέγεθος6 pagesen
ΤίτλοςMiRNA based pathway analysis tool in nephroblastoma as a proof of principle for other cancer domainsen
ΔημιουργόςZervakis Michalisen
ΔημιουργόςΖερβακης Μιχαληςel
ΔημιουργόςMoustakis Vasilisen
ΔημιουργόςΜουστακης Βασιληςel
ΔημιουργόςPotamias, Georgiosen
ΔημιουργόςL. Koumakisen
ΔημιουργόςN. Grafen
ΕκδότηςInstitute of Electrical and Electronics Engineersen
ΠερίληψηWilms tumor, or nephroblastoma, is a cancer of the kidneys that typically occurs in children and rarely in adults. Around 10% of Wilms tumor patients are diagnosed having a concurrent syndrome that enhances the risk of Wilms tumor. A screening method for early detection of Wilms tumor in these patients would be beneficial, since the size or stage of a tumor is related to outcome. We introduce a miRNA pathway analysis methodology that takes into account the topology and regulation mechanisms of the gene regulatory networks and identify disrupted sub-paths in known pathways, using miRNA- expressions. The methodology was applied on a miRNA-expression study and a predictive model was developed, using machine-learning (decision-tree induction) approaches. The model is able to identify putative mechanisms that underlie and govern the Wilms tumor phenotype, and discriminate between diseased and healthy subjects. Initial experimental results are promising and in line with the relevant biomedical literature.en
ΤύποςΠλήρης Δημοσίευση σε Συνέδριοel
ΤύποςConference Full Paperen
Άδεια Χρήσηςhttp://creativecommons.org/licenses/by/4.0/en
Ημερομηνία2015-10-25-
Ημερομηνία Δημοσίευσης2014-
Θεματική ΚατηγορίαBasic medical sciencesen
Θεματική ΚατηγορίαBasic sciences, Medicalen
Θεματική ΚατηγορίαBiomedical sciencesen
Θεματική ΚατηγορίαHealth sciencesen
Θεματική ΚατηγορίαPreclinical sciencesen
Θεματική ΚατηγορίαSciences, Medicalen
Θεματική Κατηγορίαmedical sciencesen
Θεματική Κατηγορίαbasic medical sciencesen
Θεματική Κατηγορίαbasic sciences medicalen
Θεματική Κατηγορίαbiomedical sciencesen
Θεματική Κατηγορίαhealth sciencesen
Θεματική Κατηγορίαpreclinical sciencesen
Θεματική Κατηγορίαsciences medicalen
Βιβλιογραφική ΑναφοράL. Koumakis, G. Potamias, S. Sfakianakis, V. Moustakis, M. Zervakis, N. Graf, M.Tsiknakis ,"MiRNA based pathway analysis tool in nephroblastoma as a proof of principle for other cancer domains,"in 2014 Intern.l Conf. on Bioinf. and Bioeng. (BIBE),pp.179 - 184.doi:10.1109/BIBE.2014.15en

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