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MiRNA based pathway analysis tool in nephroblastoma as a proof of principle for other cancer domains

Zervakis Michalis, Moustakis Vasilis, Potamias, Georgios, L. Koumakis, N. Graf

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URIhttp://purl.tuc.gr/dl/dias/AFA56D75-D910-4B69-BCAB-B0AD65287C01-
Identifierhttps://doi.org/10.1109/BIBE.2014.15-
Languageen-
Extent6 pagesen
TitleMiRNA based pathway analysis tool in nephroblastoma as a proof of principle for other cancer domainsen
CreatorZervakis Michalisen
CreatorΖερβακης Μιχαληςel
CreatorMoustakis Vasilisen
CreatorΜουστακης Βασιληςel
CreatorPotamias, Georgiosen
CreatorL. Koumakisen
CreatorN. Grafen
PublisherInstitute of Electrical and Electronics Engineersen
Content SummaryWilms tumor, or nephroblastoma, is a cancer of the kidneys that typically occurs in children and rarely in adults. Around 10% of Wilms tumor patients are diagnosed having a concurrent syndrome that enhances the risk of Wilms tumor. A screening method for early detection of Wilms tumor in these patients would be beneficial, since the size or stage of a tumor is related to outcome. We introduce a miRNA pathway analysis methodology that takes into account the topology and regulation mechanisms of the gene regulatory networks and identify disrupted sub-paths in known pathways, using miRNA- expressions. The methodology was applied on a miRNA-expression study and a predictive model was developed, using machine-learning (decision-tree induction) approaches. The model is able to identify putative mechanisms that underlie and govern the Wilms tumor phenotype, and discriminate between diseased and healthy subjects. Initial experimental results are promising and in line with the relevant biomedical literature.en
Type of ItemΠλήρης Δημοσίευση σε Συνέδριοel
Type of ItemConference Full Paperen
Licensehttp://creativecommons.org/licenses/by/4.0/en
Date of Item2015-10-25-
Date of Publication2014-
SubjectBasic medical sciencesen
SubjectBasic sciences, Medicalen
SubjectBiomedical sciencesen
SubjectHealth sciencesen
SubjectPreclinical sciencesen
SubjectSciences, Medicalen
Subjectmedical sciencesen
Subjectbasic medical sciencesen
Subjectbasic sciences medicalen
Subjectbiomedical sciencesen
Subjecthealth sciencesen
Subjectpreclinical sciencesen
Subjectsciences medicalen
Bibliographic CitationL. Koumakis, G. Potamias, S. Sfakianakis, V. Moustakis, M. Zervakis, N. Graf, M.Tsiknakis ,"MiRNA based pathway analysis tool in nephroblastoma as a proof of principle for other cancer domains,"in 2014 Intern.l Conf. on Bioinf. and Bioeng. (BIBE),pp.179 - 184.doi:10.1109/BIBE.2014.15en

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