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Searching for significant genes in cancer metastasis by tissue comparisons

Zervakis Michalis, Stelios Sfakianakis, Dimitris Kafetzopoulos, Dimitra Iliopoulou, Stelios Sfakianakis, Ekaterini S. Bei

Απλή Εγγραφή


URIhttp://purl.tuc.gr/dl/dias/A98D4390-D293-4671-A62D-2A5BB18BFB18-
Αναγνωριστικόhttps://doi.org/10.1007/978-3-319-11128-5_148-
Γλώσσαen-
Μέγεθος4 pagesen
ΤίτλοςSearching for significant genes in cancer metastasis by tissue comparisons en
ΔημιουργόςZervakis Michalisen
ΔημιουργόςΖερβακης Μιχαληςel
ΔημιουργόςStelios Sfakianakisen
Δημιουργός Dimitris Kafetzopoulosen
ΔημιουργόςDimitra Iliopoulouen
ΔημιουργόςStelios Sfakianakisen
ΔημιουργόςEkaterini S. Beien
ΕκδότηςSpringer Verlagen
ΠερίληψηDNA Microarrays allow scientists to simultaneously measure the expression levels of thousands of genes. However, an important need arises as to identify those genes closely associated with a particular state of interest, such as cancer, in order to discover useful biological information and efficiently classify new samples. The identification of marker genes is often based on the differential expression of groups of genes and/or their predictive potential manifested in classification experiments. Important aspects that need to be verified on both biological and statistical grounds are the actual problem considered and the algorithmic method selected. In this paper we consider the question of gene differentiation in cancer and how it can be explored through blood sample analysis. We study two algorithmic approaches based on support and relevance vector machines. The results indicate that the latter concept performs better in the specific biological environment, extracting meaningful biological concepts.en
ΤύποςΠλήρης Δημοσίευση σε Συνέδριοel
ΤύποςConference Full Paperen
Άδεια Χρήσηςhttp://creativecommons.org/licenses/by/4.0/en
Ημερομηνία2015-10-25-
Ημερομηνία Δημοσίευσης2012-
Θεματική ΚατηγορίαAdducts, DNAen
Θεματική Κατηγορίαdna adductsen
Θεματική Κατηγορίαadducts dnaen
Θεματική ΚατηγορίαBiomedical scientistsen
Θεματική ΚατηγορίαHealth scientistsen
Θεματική Κατηγορίαmedical scientistsen
Θεματική Κατηγορίαbiomedical scientistsen
Θεματική Κατηγορίαhealth scientistsen
Βιβλιογραφική ΑναφοράN.K. Chlis, S.Sfakianakis, E.S. Bei, D. Iliopoulou, D. Kafetzopoulos, M. Zervakis ," Searching for significant genes in cancer metastasis by tissue comparison,"in 2015 6th Europ. Conf. of the Intern. Federation for Medical and Biol. Engineering ,pp.594-597.doi:10.1007/978-3-319-11128-5_148en

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