Το έργο με τίτλο Solving the PIHNA model while accounting for radiotherapy από τον/τους δημιουργό/ούς Zervakis Michalis, Sakkalis, Vangelis, Roniotis Alexandros, Tzamali, Ekaterini, G.Tzetaki διατίθεται με την άδεια Creative Commons Αναφορά Δημιουργού 4.0 Διεθνές
Βιβλιογραφική Αναφορά
A. Roniotis, V. Sakkalis, E. Tzamali, G. Tzedakis, M. Zervakis, K.Marias .(2012).Solving the PIHNA model while accounting for radiotherapy.Presenta at 5th International Advanced Research Workshop in In Silico Oncology and Cancer Investigation.[online].Available: http://www.researchgate.net/profile/Georgios_Stamatakos/publication/234110079_Proceedings_of_the_2012_5th_International_Advanced_Research_Workshop_on_In_Silico_Oncology_and_Cancer_Investigation__The_TUMOR_Project_Workshop_(IARWISOCI)_OPEN_ACCESS_VER
Glioblastoma is the most aggressive type of glioma. During the last decades, several models have been proposed for simulating the growth procedure of glioma. One of the latest proposed models builds upon the proliferation - diffusion model by incorporating the angiogenic net rates and different concentration of cell populations (normoxic, hypoxic and necrotic). This proliferation- invasion- hypoxia- necrosis-angiogenesis model (PIHNA) does not take into account radiotherapy. This work presents the mathematical foundation for solving PIHNA model in two dimensions with incorporated radiotherapy effect using the Linear Quadratic Model, which uses radiobiology parameters.