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The role of the glycolysis-related genes in brain gliomas treatment design

Zervakis Michalis, M.G. Kounelakis, G.C. Giakos, X. Kotsiakis

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URIhttp://purl.tuc.gr/dl/dias/C2604C02-EA37-4048-84BF-8E569E6DA412-
Identifierhttps://doi.org/10.1007/978-3-642-23508-5_98-
Languageen-
Extent4 pagesen
TitleThe role of the glycolysis-related genes in brain gliomas treatment designen
CreatorZervakis Michalisen
CreatorΖερβακης Μιχαληςel
CreatorM.G. Kounelakisen
CreatorG.C. Giakosen
CreatorX. Kotsiakisen
PublisherSpringer Verlagen
Content SummaryThe aim of this study is to reveal the significance of glycolysis-related genes in the design of new brain gliomas treatment protocols. Towards this direction a feature selection and classification method, embedding the Relief-F filter criterion under a Support Vector Machines (SVM) classifier, has been introduced focusing on the identification of significant genetic alterations related to glycolysis. In particular a genomic (Microarray Expression) dataset, consisting of 14 glioma patients has been used for the statistical analysis. The results have demonstrated that a specific group of gene markers (HK, PGI, PFK, ALDO, GAPDH, PGK, PGM, ENO, PK, LDH, PDH and MDH) directly related to cell glycolysis, have a great impact on the discrimination of different grades of gliomas malignancy (AUROC of 0.98), thus leading to the conclusion that these markers could establish the foundations for new therapeutic approaches.en
Type of ItemΠλήρης Δημοσίευση σε Συνέδριοel
Type of ItemConference Full Paperen
Licensehttp://creativecommons.org/licenses/by/4.0/en
Date of Item2015-10-24-
Date of Publication2011-
SubjectClinical laboratory techniciansen
SubjectMedical laboratory techniciansen
Subjectmedical technologistsen
Subjectclinical laboratory techniciansen
Subjectmedical laboratory techniciansen
Bibliographic CitationM. G. Kounelakis, M. E. Zervakis, G. C. Giakos, X. Kotsiakis ,"The role of the glycolysis-related genes in brain gliomas treatment design ," in 2011 5th European Conf. of the Intern.Federation for Med. and Biological Eng. ,pp. 377-380.doi:10.1007/978-3-642-23508-5_98en

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