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Institutional Repository [SANDBOX]
Technical University of Crete
Technical University of Crete
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| URI: | http://purl.tuc.gr/dl/dias/C2604C02-EA37-4048-84BF-8E569E6DA412 | ||
| Year | 2011 | ||
| Type of Item | Conference Full Paper | ||
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| Bibliographic Citation | M. G. Kounelakis, M. E. Zervakis, G. C. Giakos, X. Kotsiakis ,"The role of the glycolysis-related genes in brain gliomas treatment design ," in 2011 5th European Conf. of the Intern.Federation for Med. and Biological Eng. ,pp. 377-380.doi:10.1007/978-3-642-23508-5_98 https://doi.org/10.1007/978-3-642-23508-5_98 | ||
| Appears in Collections |
The aim of this study is to reveal the significance of glycolysis-related genes in the design of new brain gliomas treatment protocols. Towards this direction a feature selection and classification method, embedding the Relief-F filter criterion under a Support Vector Machines (SVM) classifier, has been introduced focusing on the identification of significant genetic alterations related to glycolysis. In particular a genomic (Microarray Expression) dataset, consisting of 14 glioma patients has been used for the statistical analysis. The results have demonstrated that a specific group of gene markers (HK, PGI, PFK, ALDO, GAPDH, PGK, PGM, ENO, PK, LDH, PDH and MDH) directly related to cell glycolysis, have a great impact on the discrimination of different grades of gliomas malignancy (AUROC of 0.98), thus leading to the conclusion that these markers could establish the foundations for new therapeutic approaches.
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