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Shape-influenced clustering of dynamic patterns of gene profiles

Georgia Skreti, Ekaterini S. Bei, Zervakis Michalis

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URIhttp://purl.tuc.gr/dl/dias/795F0C0B-928D-4020-B47A-501EEC8031BC-
Identifierhttps://doi.org/10.1109/EMBC.2012.6346161-
Languageen-
Extent4 pagesen
TitleShape-influenced clustering of dynamic patterns of gene profilesen
CreatorGeorgia Skretien
Creator Ekaterini S. Beien
CreatorZervakis Michalisen
CreatorΖερβακης Μιχαληςel
PublisherInstitute of Electrical and Electronics Engineersen
Content SummaryStatistical evaluation of temporal gene expression profiles plays an important role in particular biological processes and conditions. We introduce a clustering method for this purpose, which is based on the expression patterns but is also influenced by temporal changes. We compare the results of our platform with methods based on expression or the rank of temporal changes. The proposed platform is illustrated with a temporal gene expression dataset comprised of primary human chondrocytes and mesenchymal stem cells (MSCs). We derived three clusters in each cell type and compared the content of these classes in terms of temporal changes, which can support biological performance. For statistical evaluation we introduce a validity measure that takes under consideration these temporal changes and we also perform an enrichment analysis of three central genes in each cluster. Even though we can detect certain statistical similarities, these might be due to different biological processes. Our proposed platform contributes to both the statistical and biological validation of temporal profiles.en
Type of ItemΠλήρης Δημοσίευση σε Συνέδριοel
Type of ItemConference Full Paperen
Licensehttp://creativecommons.org/licenses/by/4.0/en
Date of Item2015-10-24-
Date of Publication2012-
SubjectClinical laboratory techniciansen
SubjectMedical laboratory techniciansen
Subjectmedical technologistsen
Subjectclinical laboratory techniciansen
Subjectmedical laboratory techniciansen
Bibliographic CitationG. Skreti, E. S. Bei, M.Zervakis ,"Shape-influenced clustering of dynamic patterns of gene profiles," in 2012 Annual International Conf. of the IEEE Eng. in Medicine and Biol. Society (EMBC),pp.1238-1241.doi:10.1109/EMBC.2012.6346161en

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