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A complete mathematical study of a 3D model of heterogeneous and anisotropic glioma evolution

Zervakis Michalis, Roniotis Alexandros, Sakkalis, Vangelis

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URIhttp://purl.tuc.gr/dl/dias/95EC6A33-E648-49BC-9BDA-98E50AC0FCC9-
Identifierhttps://doi.org/10.1109/IEMBS.2009.5333776-
Languageen-
Extent4 pagesen
TitleA complete mathematical study of a 3D model of heterogeneous and anisotropic glioma evolutionen
CreatorZervakis Michalisen
CreatorΖερβακης Μιχαληςel
CreatorRoniotis Alexandrosen
CreatorΡονιωτης Αλεξανδροςel
CreatorSakkalis, Vangelisen
PublisherInstitute of Electrical and Electronics Engineersen
Content SummaryGlioma is the most aggressive type of brain cancer. Several mathematical models have been developed towards identifying the mechanism of tumor growth. The most successful models have used variations of the diffusion-reaction equation, with the recent ones taking into account brain tissue heterogeneity and anisotropy. However, to the best of our knowledge, there hasn't been any work studying in detail the mathematical solution and implementation of the 3D diffusion model, addressing related heterogeneity and anisotropy issues. To this end, this paper introduces a complete mathematical framework on how to derive the solution of the equation using different numerical approximation of finite differences. It indicates how different proliferation rate schemes can be incorporated in this solution and presents a comparative study of different numerical approaches.en
Type of ItemΠλήρης Δημοσίευση σε Συνέδριοel
Type of ItemConference Full Paperen
Licensehttp://creativecommons.org/licenses/by/4.0/en
Date of Item2015-10-23-
Date of Publication2009-
SubjectMedicalen
Bibliographic CitationA. Roniotis, K. Marias, V. Sakkalis, G.D. Tsibidis, M. Zervakis," A complete mathematical study of a 3D model of heterogeneous and anisotropic glioma evolution,"in 2009 Annual Inter. Conf. of the IEEE Eng. in Medicine and Biol. Society EMBC,pp.2807 - 2810.doi:10.1109/IEMBS.2009.5333776en

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