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Oxygenation capabilities of basket-type bioreactors for microcarrier cultures of anchorage-dependent cells

Kalogerakis Nikos, Behie L.A.

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URI: http://purl.tuc.gr/dl/dias/0A87B318-1134-46BF-9BE1-06C3488F3F81
Year 1997
Type of Item Peer-Reviewed Journal Publication
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Bibliographic Citation N. Kalogerakis, and L.A. Behie,"Oxygenation capabilities of basket-type bioreactors for microcarrier cultures of anchorage-dependent cells," Bioprocess and Biosystems Engineering, vol. 17, no. 3, pp. 151-156, Jul. 1997. doi: 10.1007/s004490050369 https://doi.org/10.1007/s004490050369
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Summary

The oxygenation capabilities of a new generation three phase - two region 1200 l bioreactor employed for the cultivation of anchorage dependent animal cells were investigated experimentally. A mathematical model has also been developed that explains qualitatively the observed oxygenation characteristics. This type of bioreactor, that uses microcarrier support particles, has two distinct mesh-separated regions so that the air bubbles in the oxygenation region do not come into contact with the microcarriers in the cell (bubble-free) region. Implications on achievable maximum cell densities are also discussed.

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