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In silico modeling and global optimization of dynamic bio-optical processes for probing, in vivo, biological features of neoplasia

Balas Costas, Papoutsoglou Georgios, Stamatiadou M.

Πλήρης Εγγραφή


URI: http://purl.tuc.gr/dl/dias/AC0EB294-A074-48E3-9FD4-0524AEB1B0D8
Έτος 2012
Τύπος Δημοσίευση σε Περιοδικό με Κριτές
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Λεπτομέρειες
Βιβλιογραφική Αναφορά G. Papoutsoglou, M. Stamatiadou, C. Balas "In silico modeling and global optimization of dynamic bio-optical processes for probing, in vivo, biological features of neoplasia" IEEE-iCBCB 2012, Macau, China May 28-30, 2012,DOI:10.1109/iCBEB.2012.474 https://doi.org/10.1109/iCBEB.2012.474
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Περίληψη

We present the first in silico simulation of biomarker uptake kinetics and of the associated dynamic optical signals, measured in vivo in neoplastic epithelial tissue. We introduce a new, non-invasive method for estimating and mapping of both structural and functional, neoplasia-correlated parameters. The method relies on model-based fitting of dynamic optical signals, measured in vivo, and on solving the inverse problem with the aid of global sensitivity analysis and global optimization approaches.

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