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In vivo dynamic imaging, in silico modeling and global sensitivity analysis for the study and the diagnosis of epithelial neoplasia

Stavrakakis Georgios, Papoutsoglou Georgios, Anastasopoulou Angeliki, C. Balas , P. Souter

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URIhttp://purl.tuc.gr/dl/dias/B5BBA6BB-E40B-4234-A5A7-94AB4FB5536C-
Αναγνωριστικόhttps://doi.org/10.1109/IEMBS.2011.6089905. -
Γλώσσαen-
Μέγεθος5 pagesen
ΤίτλοςIn vivo dynamic imaging, in silico modeling and global sensitivity analysis for the study and the diagnosis of epithelial neoplasiaen
ΔημιουργόςStavrakakis Georgiosen
ΔημιουργόςΣταυρακακης Γεωργιοςel
ΔημιουργόςPapoutsoglou Georgiosen
ΔημιουργόςΠαπουτσογλου Γεωργιοςel
ΔημιουργόςAnastasopoulou Angelikien
ΔημιουργόςΑναστασοπουλου Αγγελικηel
ΔημιουργόςC. Balas en
ΔημιουργόςP. Souteren
ΠερίληψηWe present a method for detecting and studying neoplasia-specific functional and structural features through the combination of in vivo dynamic imaging, in silico modeling and global sensitivity analysis. We particularly present the case of cervical epithelium interacting with acetic acid solution, which is employed as an optical biomarker. The in vivo measured dynamic scattering characteristics are strongly correlated with the output of the biomarker's pharmacokinetic model that we have developed. Model global sensitivity analysis has shown that the measured/modeled bio-optical processes can be used for probing, in vivo, the number of neoplastic layers, the extracellular pH, the intracellular buffering efficiency and the size of the extracellular space.en
ΤύποςΑφίσα σε Συνέδριοel
ΤύποςConference Posteren
Άδεια Χρήσηςhttp://creativecommons.org/licenses/by/4.0/en
Ημερομηνία2015-10-15-
Ημερομηνία Δημοσίευσης2011-
Θεματική ΚατηγορίαMedicineen
Βιβλιογραφική ΑναφοράG. Papoutsoglou ,A. Anastasopoulou, G. Stavrakakis ,P. Soutter ,C.Balas ,"In vivo dynamic imaging, in silico modeling and global sensitivity analysis for the study and the diagnosis of epithelial neoplasia,"in 2011 33rd Annual Inter. Conf. of the IEEE EMBS,pp.95-99.doi: 10.1109/IEMBS.2011.6089905.en

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