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Genetic data analysis for classification of bipolar disorders

Leska Valsamo

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URIhttp://purl.tuc.gr/dl/dias/F907111A-7932-4E21-9D25-5DB808FC7B60-
Αναγνωριστικόhttps://doi.org/10.26233/heallink.tuc.31880-
Γλώσσαen-
Μέγεθος95 pagesen
ΤίτλοςGenetic data analysis for classification of bipolar disordersen
ΔημιουργόςLeska Valsamoen
ΔημιουργόςΛεσκα Βαλσαμωel
Συντελεστής [Επιβλέπων Καθηγητής]Zervakis Michalisen
Συντελεστής [Επιβλέπων Καθηγητής]Ζερβακης Μιχαληςel
Συντελεστής [Μέλος Εξεταστικής Επιτροπής]Balas Costasen
Συντελεστής [Μέλος Εξεταστικής Επιτροπής]Μπαλας Κωσταςel
Συντελεστής [Μέλος Εξεταστικής Επιτροπής]Petrakis Evripidisen
Συντελεστής [Μέλος Εξεταστικής Επιτροπής]Πετρακης Ευριπιδηςel
ΕκδότηςTechnical University of Creteen
ΕκδότηςΠολυτεχνείο Κρήτηςel
Ακαδημαϊκή ΜονάδαTechnical University of Crete::School of Electronic and Computer Engineeringen
Ακαδημαϊκή ΜονάδαΠολυτεχνείο Κρήτης::Σχολή Ηλεκτρονικών Μηχανικών και Μηχανικών Υπολογιστώνel
ΠερίληψηIn the resent years DNA microarray analysis has become a widely used tool for gene expression profiling and data analysis. This technology can be useful in the classification of complex diseases such as bipolar disorder, providing useful information for its genetic background. Bipolar disorder is a common, heritable mental illness characterized by recurrent episodes of mania and depression that manifests from multiple genetic and environmental factors. There are four basic types of bipolar disorder; bipolar I disorder, dipolar II disorder, Bipolar Disorder Not Otherwise Specified (BP-NOS) and Cyclothymic. The ability to classify dipolar disorders may have a major impact on our understanding of disease pathophysiology and may provide important opportunities to investigate the interaction between genetic and environmental factors involved in pathogenesis. Also this ability may be essential to guide appropriate therapy and determine prognosis for successful treatment. The aim of this diploma thesis is to extract a significant genomic signature for which biological knowledge already exists or discover novel genomic information, which might stand as the motivation for further analysis. Under this genomic signature we classify the bipolar disorders using gene expressions from two different populations. Microarray analysis normally leads to datasets which contain a small number of samples which have a large number of gene expression levels as features. In order to extract useful informative sets of genes that can reduce dimensionality and maximize the performance of classifiers, feature selection algorithms were used. Another aim of this study is to achieve stable performance assessment of feature selection and classification methods. In that manner, the genetic evaluation framework named “Stable Bootstrap Validation” (SBV), introduced be Nick Chlis, is presented. The SBV utilizes bootstrap resampling of the original dataset and an explicit criterion that determines the stability of the observed classification accuracy and the biological interpretation of genes, also called genomic signature. Moreover, methodologies for evaluating the discrimination, consistency and generalization ability of the observed results are also introduced. In this diploma thesis a unified “32 common gene signature” was extracted, which is closely associated with several aspect of bipolar disorders. en
ΤύποςΔιπλωματική Εργασίαel
ΤύποςDiploma Worken
Άδεια Χρήσηςhttp://creativecommons.org/licenses/by/4.0/en
Ημερομηνία2015-09-25-
Ημερομηνία Δημοσίευσης2015-
Θεματική ΚατηγορίαBipolar depressionen
Θεματική ΚατηγορίαBipolar disorderen
Θεματική ΚατηγορίαDepression, Bipolaren
Θεματική ΚατηγορίαDepression, Manicen
Θεματική ΚατηγορίαManic depressionen
Θεματική ΚατηγορίαManic-depressive psychosesen
Θεματική ΚατηγορίαManic-depressive psychosisen
Θεματική ΚατηγορίαMelancholiaen
Θεματική Κατηγορίαmanic depressive illnessen
Θεματική Κατηγορίαbipolar depressionen
Θεματική Κατηγορίαbipolar disorderen
Θεματική Κατηγορίαdepression bipolaren
Θεματική Κατηγορίαdepression manicen
Θεματική Κατηγορίαmanic depressionen
Θεματική Κατηγορίαmanic depressive psychosesen
Θεματική Κατηγορίαmanic depressive psychosisen
Θεματική Κατηγορίαmelancholiaen
Θεματική ΚατηγορίαBio-informaticsen
Θεματική ΚατηγορίαBiological informaticsen
Θεματική Κατηγορίαbioinformaticsen
Θεματική Κατηγορίαbio informaticsen
Θεματική Κατηγορίαbiological informaticsen
Βιβλιογραφική ΑναφοράValsamo Leska, "Genetic data analysis for classification of bipolar disorders", Diploma Work, School of Electronic and Computer Engineering, Technical University of Crete, Chania, Greece, 2015en

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